Day Zero Diagnostics


Contact Jong Lee
Title CEO & Co-Founder


The future of infectious disease diagnostics starts at Day Zero. By using whole-genome sequencing (WGS) and our proprietary enabling technologies, Day Zero is creating a new class of sequencing-based in-vitro diagnostics that generates clinically actionable data at scale. Our technologies include novel sample preparation methods enabling unprecedented ultra-high enrichment of pathogen DNA for sequencing directly from clinical samples, machine learning algorithms that provide clinically actionable diagnostic results, and a world-class database of WGS and drug efficacy profiles. Day Zero Diagnostics is on a mission to transform the way infectious disease diagnostics are performed by generating the stream of real-time sequencing data required to change how we track, manage and combat infectious diseases.

With an enormous unmet clinical and economic need, we are targeting bloodstream infections and sepsis for our first application. The life expectancy of a patient with septic shock is 24 hours without fast effective antibiotic treatment. However, even when successful, current diagnostics take 2-5 days to identify the pathogen AND provide its antibiotic susceptibility profile. The lack of rapid, accurate, and comprehensive diagnostics, forces physicians to “carpet bomb” patients with severe infections with powerful, yet toxic, broad-spectrum antibiotics, which is not only ineffective in many cases but can also lead to significant morbidity and mortality. Day Zero delivers a complete diagnosis, including both the species and antibiotic resistance profile, in hours vs. days, enabling the physician to use a targeted treatment on day zero of hospital admission and resulting in better patient outcomes and cost savings.

Company News

Top Boston Startups to Watch in 2021, featuring Day Zero Diagnostics

DateJul 19, 2021
The total early-stage startup funding in the ecosystem dwarves the global average of $431 Million with a total of $3.9 Billion. The ecosystem is also worth almost ten times that of the average global ecosystem.
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Day Zero Diagnostics Wins $300K NIH Grant to Refine HAI Outbreak Analysis Service

DateDec 9, 2020
Infectious disease startup Day Zero Diagnostics last week received a $300,000 grant from the National Institutes of Health to further develop its nanopore sequencing-based technology for the analysis of healthcare-associated infection (HAI) outbreaks.
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Day Zero Diagnostics wins $6.2m from accelerator

DateMay 12, 2020
Boston-based Day Zero said in a news release that its system helps offer the most effective antibiotic treatment on the first day that patients are admitted to the hospital, rather than having them undergo multiple days of toxic broad-spectrum antibiotics to prevent septic shock.
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Day Zero Diagnostics: New Diagnostic Rapidly Identifies The Resistance Profile of Bacteria, Enabling Targeted Therapy Sooner

DateJan 17, 2018
At the 2017 meeting of AdvaMed, the medical device industry’s advocacy organization, young start-up Day Zero Diagnostics was chosen as this year’s MedTech Innovator Global Competition winner.