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Real-time intraoperative confocal laser endomicroscopy with on-site neuropathologist consultation for glioma margin assessment: illustrative case featuring VPIX Medical

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This report presents an illustrative case demonstrating a practical collaborative workflow that integrates CLE with on-site neuropathologist consultation for real-time margin assessment during glioma resection. We used the cCeLL-In vivo system (VPIX Medical Inc.), a handheld CLE device with US Food and Drug Administration 510(k) clearance for microscopic tissue visualization.5,6 The case highlights how this collaborative approach addresses both the technical capabilities and the interpretive challenges of intraoperative CLE implementation.

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