Histology in your hands: cross-modal imaging shows living skin in full color featuring Enspectra Health
A long-sought goal in dermatology is the development of an imaging modality with sufficient resolution and compositional detail to noninvasively display skin histology in vivo. Here, we describe a system that achieves this goal using cross-sectionally scanned, multimodal microscopy (cross-modal).
A long-sought goal in dermatology has been the development of an imaging modality with sufficient resolution and compositional detail to noninvasively interrogate skin histology in vivo. Impressive technologies have emerged in this field, such as RCM, multi-photon microscopy (MPM), OCT, and line-field confocal OCT (LC-OCT). These technologies have generated evidence supporting their ability to better identify disease noninvasively; however, each has limitations when used as a stand-alone tool. Driven by practical clinical needs, we sought to develop an imaging modality that offers noninvasive, real-time cross-sectional skin imaging in a compact, intuitive form. We aimed to incorporate exceptional imaging performance to support a future of diagnostic capabilities across various skin types and conditions. In our publication, we introduce a new technology—cross-modal imaging—that addresses these clinical needs. Our cross-modal system combines multiphoton and pinhole-free reflectance confocal microscopy into one compact system with a handheld wand using a single Class 1M, 780 nm ultrafast pulsed near-infrared (NIR) light source.
